The present research work discusses the development of a simple, accurate and cost effective UV spectroscopic method for the estimation of aprepitant in bulk as well as capsule formulation. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λmax) was found to be 264 nm. The validation was performed as per ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The method shows high sensitivity with linearity in the range of 10‐120 µg/ml. The calibration curve shows a linear relationship between the absorbance and concentration with coefficient of correlation 0.999053. The regression of curve was y = 0.00441x + 0.00333. The precision of method was found to be good. The percentage recovery was found to be 100% ± SD. The optimized method showed good reproducibility and recovery. The standard error in case of recovery studies are satisfactorily low and allow estimation of aprepitant in concentration range employed in the assay of bulk drugs and capsules. The sample solution was observed to be stable upto 48 hours. It is thus concluded that the proposed method is new, simple, cost‐effective, safe, accurate, environmental friendly and can be used as quality control method for bulk as well as pharmaceutical formulations.
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